Table 2.

In vitro kinase activity of TPX-0005.

Target	IC50 (nM) at 10 μM ATP	Target	IC50 (nM) at 10 μM ATP	Target	IC50 (nM) at 10 μM ATP
TRKB	0.05	SNARK	13.0	JAK3	50
ROS1	0.07	HCK	16.4	EPHA8	50.2
TRKC	0.1	IRR	18.1	IGFR	111
TRKA	0.83	LCK	18.6	PLK4	126
ALK	1.04	JAK1	19	AXL	149
JAK2	1.04	TYK2	21.6	MARK3	512
FYN	1.05	LTK	21.8
LYN	1.66	DDR2	23
YES	2.15	BTK	23.7
FGR	3.05	TNK2	24.1
TXK	3.17	EPHA1	25.0
ARK5	4.46	BLK	32.3
SRC	5.3	GRK7	35.2
DDR1	5.7	PYK2	39.9
FAK	6.96	RET	47.1