Table 3.

IC₅₀ values and combination indexes of first-, second- and third-generation EGFR inhibitors in combination with TPX-0005 tested in EGFR-mutation-positive cell lines.

	IC50 (μM)					Combination Index
	Gefitinib	Afatinib	Dacomitinib	Osimertinib	TPX-0005	Gefitinib + TPX-0005	Afatinib + TPX-0005	Dacomitinib + TPX-0005	Osimertinib + TPX-0005
PC9	0.05	<0.01	<0.01	0.02	1.00	0.68 synergism	0.80 synergism	0.57 synergism	0.60 synergism
H1975	10.00	0.04	0.15	0.02	1.00	0.84 additive	1.12 additive	0.84 additive	0.61 synergism
11–18	0.80	0.03	0.01	0.06	1.50	0.64 synergism	0.76 synergism	0.64 synergism	0.62 synergism
HCC4006	0.03	<0.01	<0.01	0.01	1.48	0.92 additive	0.93 additive	0.66 synergism	0.56 synergism
HCC827	0.02	<0.01	<0.01	0.01	0.43	0.75 synergism	0.73 synergism	0.63 synergism	0.75 synergism