Fig. 1.

Evoked responses indicating enhanced activity in the subiculum, revealed by flavoprotein fluorescence imaging. (a) Representative images of tissue from each of the Ex-hipp, No-HS and HS groups. Solid circles indicate stimulation points. Note the enhanced responses in the subiculum of patients with No-HS and HS. In HS, stimulation of mossy fibers elicits a response in the dentate granule cell layer (arrow in the panel “CA4”). All images were obtained at 1.2 s after stimulation onset. Scale bar: 1 mm. (b, c) Quantitative analysis of the peak amplitudes (b) and responded area >0.5% of the subiculum (c) are shown. Error bars, S.E.M. *p < .05 and **p < .01, Tukey-Kramer test after one-factor ANOVA.