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. 2018 Apr 23;8:100. doi: 10.3389/fonc.2018.00100

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Copyright © 2018 Aref-Eshghi, Schenkel, Ainsworth, Lin, Rodenhiser, Cutz and Sadikovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene-set enrichment analysis of differentially methylated cytosine-phosphate-guanine sites (CpGs) in prostate cancer: (A) multiple dimensional scaling of the gene ontology (GO) terms (circles): GO terms with closely related functionalities are clustered in groups. Circles with smaller distance from each other represent GO terms with similar functionality. The uniqueness of every GO term is shown using a color scale from blue (less unique) to red (more unique). Representative non-redundant GO terms from every cluster are written next to the related circles. Only 350 of the GO terms were selected by REVIGO for reduction and visualization (maximum software limit); (B) hierarchical relationship between the significant GO terms: the level of significance (p-value) of every functional category is illustrated by a color scale from white to blue.