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. 2018 Apr 23;9:854. doi: 10.3389/fimmu.2018.00854

Figure 7.

Figure 7

Decreased levels of antioxidant enzymes and hydrogen sulfide enzymes in NF-E2-related factor 2 (Nrf2)-deficient mice. Nrf2 KO and wild type (WT) mice were infected with respiratory syncytial virus (RSV) or PBS and harvested at day 1 post-infection to isolate total RNA from lungs. (A) Catalase (left panel) and Cu/Zn-superoxide dismutase-1 (right panel) gene expression were quantified by quantitative real-time PCR (and expressed as fold change). The bar graph represents mean ± SEM (n = 3 mice/group). *p < 0.05 Nrf2 KO/RSV vs. Nrf2 KO/PBS, **p < 0.01 Nrf2 KO/PBS vs. WT/PBS, WT/RSV vs. WT/PBS, and Nrf2 KO/RSV vs. WT/RSV, ***p < 0.001 Nrf2 KO/RSV vs. Nrf2 KO/PBS. (B) CSE, CBS, and 3-mercaptopyruvate sulfurtransferase mRNA levels were measured by quantitative real-time PCR (expressed as fold change). The bar graph represents mean ± SEM (n = 3 mice/group). *p < 0.05 Nrf2 KO/RSV vs. Nrf2 KO/PBS, and Nrf2 KO/RSV vs. WT/RSV, ***p < 0.001 Nrf2 KO/RSV vs. Nrf2 KO/PBS.