TABLE 1.
Diagnostic accuracy measured by likelihood ratios
| Specimen,c culture duration (days) or 16S rRNA sequencing | No. of cases with a positive test/no. of cases tested |
LRa |
||
|---|---|---|---|---|
| PJI (n = 42) | AF (n = 66) | Positive (95% CI) | Negative (95% CI) | |
| 5-STB, 6 | 31/42 | 0/66 | Infinityb | 0.3 (0.2–0.4) |
| 5-STB, 14 | 37/42 | 0/66 | Infinity | 0.1 (0.05–0.3) |
| JF, 6 | 26/39 | 1/57 | 38 (5–269) | 0.3 (0.2–0.5) |
| JF, 14 | 34/39 | 2/56 | 24 (6–96) | 0.1 (0.06–0.3) |
| PC, 6 | 24/37 | 1/60 | 39 (5–276) | 0.4 (0.2–0.6) |
| PC, 14 | 33/37 | 5/60 | 11 (5–25) | 0.1 (0.05–0.3) |
| SW (in situ), 6 | 9/32 | 0/59 | Infinity | 0.7 (0.6–0.9) |
| SW (in situ), 14 | 16/32 | 2/59 | 15 (4–60) | 0.5 (0.4–0.7) |
| BB, 6 | 9/32 | 0/54 | Infinity | 0.8 (0.7–0.9) |
| BB, 14 | 13/32 | 1/54 | 22 (3–160) | 0.6 (0.5–0.8) |
| Periprosthetic tissue, 16S rRNA sequencing | 8/32 | 0/53 | Infinity | 0.8 (0.6–0.9) |
| Synovial fluid, 16S rRNA sequencing | 25/35 | 1/65 | 46 (7–328) | 0.3 (0.2–0.5) |
| PC, 16S rRNA sequencing | 32/37 | 1/64 | 55 (8–389) | 0.1 (0.06–0.3) |
| SW (in situ), 16S rRNA sequencing | 15/34 | 4/52 | 6 (2–16) | 0.6 (0.4–0.8) |
| BB, 16S rRNA sequencing | 4/29 | 2/47 | 3 (0.6–17) | 0.9 (0.8–1.0) |
a
Positive describes how probability of infection shifts with positive results, and negative describes how probability of infection wanes with negative results. CI, confidence interval.
b
An incalculably large number.
c
For abbreviations of specimen types, see the text.