TABLE 6.
Neutralization results for Elecsys Chagas assay-discrepant, repeatedly reactive samples from blood donors
| Study site | Comparator COI | Elecsys COIa | Elecsys COI after neutralization | Recoveryb (%) |
|---|---|---|---|---|
| Italy | 0.016 | 2.94 | 1.87 | 64 |
| Colombia | 0.023 | 1.16 | 0.298 | 26 |
| Colombia | 0.037 | 1.09 | 0.300 | 28 |
| Colombia | 0.554 | 1.47 | 0.515 | 35 |
| Argentina | 0.230 | 12.6 | 0.348 | 3 |
| Argentina | 0.99/0.97/1.14c | 40.8 | 2.04 | 5 |
| Argentina | 0.040 | 2.92 | 0.227 | 8 |
| Argentina | 0.080 | 1.60 | 0.132 | 8 |
| Argentina | 0.510 | 1.47 | 0.152 | 10 |
| Argentina | 0.030 | 1.03 | 1.01 | 98 |
a
COI as determined by Roche Diagnostics Centralized and Point of Care Solutions (Penzberg, Germany) prior to the neutralization procedure.
b
A recovery of ≤25% was assessed as successful neutralization (i.e., positive for anti-T. cruzi antibodies). Values in boldface type represent neutralizable/borderline and neutralizable samples.
c
The COI was repeatedly in the gray zone.