Skip to main content
. 2018 Mar 12;33(5):895–904. doi: 10.1093/humrep/dey050

Table I.

Effects of bisphenol A on spindle morphology in bovine metaphase II oocytes.

Ctrl fM (10−15 M) pM (10−12 M) nM (10−9 M) uM (10−6 M)
1 10 100 1 10 100 1 10 100 50
Bipolar 175 (82.9) 21(58.3) 22 (48.9) 60 (69.8) 24 (77.4) 27 (67.5) 16 (80.0) 26 (50.0) 68 (54.8) 37 (56.1) 27 (48.2)
Bipolar abn 26 (12.3) 12 (33.3) 19 (42.2) 23 (26.7) 7 (22.6) 13 (32.5) 4 (20.0) 19 (36.5) 41 (33.1) 23 (34.8) 24 (42.9)
Non-bipolar 10 (4.7) 3 (8.3) 4 (8.9) 3 (3.5) 0 (0.0) 0 (0.0) 0 (0.0) 7 (13.5) 15 (12.1) 6 (9.1) 5 (8.9)
P value 0.0129 <0.0001 0.0293 0.3216 0.0129 0.4074 <0.0001 <0.0001 0.0002 <0.0001

The number of oocytes (percentage in parentheses) with bipolar spindles, bipolar spindles with abnormalities and non-bipolar spindles are shown from at least three independent experiments per concentration. P values < 0.05 indicate a significant difference compared to control as determined by Fisher’s exact test.