Figure 11.

Role of CgYapsins in interaction with macrophages. Shown is a schematic model illustrating the role of CgYapsins in regulating the interaction of C. glabrata with THP-1 macrophages. CgYapsins modulate the macrophage transcriptional response probably to facilitate intracellular survival of C. glabrata through regulated production of Syk-dependent IL-1β. Lack of CgYapsins leads to increased IL-1β levels, which results in cell death. Altered cell wall attributes of the Cgyps1–11Δ mutant are depicted through surface ridges. Transcriptionally up-regulated and down-regulated processes in infected THP-1 cells are indicated in light brown and pink, respectively.