Figure 8.

C. glabrata infection invokes IL-1 β production in the mouse model of systemic candidiasis. Measurement of secreted IL-1β in tissue homogenates of kidneys, liver, spleen, and brain of mice infected with WT or Cgyps1–11Δ cells at the indicated days using the mouse IL-1β/IL-1F2 DuoSet ELISA kit. Data (mean ± S.E. (error bars), n = 4) represent IL-1 β levels under the indicated conditions. Statistically significant differences in IL-1β levels between uninfected and C. glabrata–infected, and WT– and Cgyps1–11Δ–infected mice are indicated by black and gray asterisks, respectively. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001; unpaired two-tailed Student's t test.