Table 1.
GO-BP enrichment analysis of DEGs in C. glabrata WT– and Cgyps1–11Δ–infected THP-1 macrophages
| GO ID | GO term | p |
|---|---|---|
| WT-infected THP-1 macrophages | ||
| Up-regulated DEGs | ||
| GO:0006935 | Chemotaxis | 0.0001 |
| GO:0007165 | Signal transduction | 0.0003 |
| GO:0006954 | Inflammatory response | 0.0003 |
| GO:0050710 | Negative regulation of cytokine secretion | 0.0008 |
| GO:0070098 | Chemokine-mediated signaling pathway | 0.0009 |
| GO:0050728 | Negative regulation of inflammatory response | 0.0015 |
| GO:0051209 | Release of sequestered calcium ion into cytosol | 0.0038 |
| GO:0001666 | Response to hypoxia | 0.0058 |
| GO:0006955 | Immune response | 0.0067 |
| GO:0007254 | JNK cascade | 0.0072 |
| GO:0051491 | Positive regulation of filopodium assembly | 0.0076 |
| GO:0043065 | Positive regulation of apoptotic process | 0.0079 |
| GO:0043401 | Steroid hormone mediated signaling pathway | 0.0121 |
| GO:0043547 | Positive regulation of GTPase activity | 0.0167 |
| GO:0060644 | Mammary gland epithelial cell differentiation | 0.0170 |
| GO:0060326 | Cell chemotaxis | 0.0189 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | 0.0190 |
| GO:0021794 | Thalamus development | 0.0196 |
| GO:0005975 | Carbohydrate metabolic process | 0.0199 |
| GO:0007049 | Cell cycle | 0.0213 |
| GO:0050729 | Positive regulation of inflammatory response | 0.0276 |
| GO:0006468 | Protein phosphorylation | 0.0280 |
| GO:0010039 | Response to iron ion | 0.0317 |
| GO:0001755 | Neural crest cell migration | 0.0333 |
| GO:0045766 | Positive regulation of angiogenesis | 0.0347 |
| GO:0007275 | Multicellular organism development | 0.0360 |
| GO:0006629 | Lipid metabolic process | 0.0373 |
| GO:0071345 | Cellular response to cytokine stimulus | 0.0460 |
| GO:2000345 | Regulation of hepatocyte proliferation | 0.0463 |
| GO:0006811 | Ion transport | 0.0496 |
| Downregulated DEGs | ||
| GO:0006954 | Inflammatory response | 0.0001 |
| GO:0043410 | Positive regulation of MAPK cascade | 0.0003 |
| GO:0060750 | Epithelial cell proliferation involved in mammary gland duct elongation | 0.0003 |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | 0.0011 |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | 0.0014 |
| GO:0097190 | Apoptotic signaling pathway | 0.0015 |
| GO:0010863 | Positive regulation of phospholipase C activity | 0.0017 |
| GO:0045778 | Positive regulation of ossification | 0.0030 |
| GO:0061036 | Positive regulation of cartilage development | 0.0054 |
| GO:0048663 | Neuron fate commitment | 0.0061 |
| GO:0060749 | Mammary gland alveolus development | 0.0061 |
| GO:0048146 | Positive regulation of fibroblast proliferation | 0.0063 |
| GO:0000187 | Activation of MAPK activity | 0.0067 |
| GO:0071346 | Cellular response to interferon-γ | 0.0073 |
| GO:1902895 | Positive regulation of pri-miRNA transcription from RNA polymerase II promoter | 0.0084 |
| GO:0032092 | Positive regulation of protein binding | 0.0088 |
| GO:0006898 | Receptor-mediated endocytosis | 0.0098 |
| GO:0006935 | Chemotaxis | 0.0105 |
| GO:0060326 | Cell chemotaxis | 0.0105 |
| GO:0001938 | Positive regulation of endothelial cell proliferation | 0.0124 |
| GO:0070098 | Chemokine-mediated signaling pathway | 0.0134 |
| GO:0072104 | Glomerular capillary formation | 0.0139 |
| GO:0055007 | Cardiac muscle cell differentiation | 0.0151 |
| GO:0008284 | Positive regulation of cell proliferation | 0.0163 |
| GO:0042981 | Regulation of apoptotic process | 0.0167 |
| GO:0014066 | Regulation of phosphatidylinositol 3-kinase signaling | 0.0172 |
| GO:0043065 | Positive regulation of apoptotic process | 0.0186 |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | 0.0196 |
| GO:0048701 | Embryonic cranial skeleton morphogenesis | 0.0196 |
| GO:0022414 | Reproductive process | 0.0208 |
| GO:0072138 | Mesenchymal cell proliferation involved in ureteric bud development | 0.0208 |
| GO:0003130 | BMP signaling pathway involved in heart induction | 0.0208 |
| GO:0030501 | Positive regulation of bone mineralization | 0.0247 |
| GO:0007188 | Adenylate cyclase-modulating G-protein–coupled receptor signaling pathway | 0.0274 |
| GO:0060686 | Negative regulation of prostatic bud formation | 0.0276 |
| GO:0045893 | Positive regulation of transcription, DNA-templated | 0.0276 |
| GO:0008584 | Male gonad development | 0.0279 |
| GO:0046854 | Phosphatidylinositol phosphorylation | 0.0279 |
| GO:0002062 | Chondrocyte differentiation | 0.0302 |
| GO:0007165 | Signal transduction | 0.0311 |
| GO:0002138 | Retinoic acid biosynthetic process | 0.0344 |
| GO:0061156 | Pulmonary artery morphogenesis | 0.0344 |
| GO:0043949 | Regulation of cAMP-mediated signaling | 0.0344 |
| GO:0060744 | Mammary gland branching involved in thelarche | 0.0344 |
| GO:0002548 | Monocyte chemotaxis | 0.0346 |
| GO:0001658 | Branching involved in ureteric bud morphogenesis | 0.0346 |
| GO:0000165 | MAPK cascade | 0.0365 |
| GO:0048015 | Phosphatidylinositol-mediated signaling | 0.0379 |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 0.0406 |
| GO:0045165 | Cell fate commitment | 0.0408 |
| GO:0003151 | Outflow tract morphogenesis | 0.0408 |
| GO:2001171 | Positive regulation of ATP biosynthetic process | 0.0411 |
| GO:0003150 | Muscular septum morphogenesis | 0.0411 |
| GO:0021978 | Telencephalon regionalization | 0.0411 |
| GO:0002320 | Lymphoid progenitor cell differentiation | 0.0411 |
| GO:0042487 | Regulation of odontogenesis of dentin-containing tooth | 0.0411 |
| GO:0071356 | Cellular response to tumor necrosis factor | 0.0416 |
| GO:0043547 | Positive regulation of GTPase activity | 0.0439 |
| GO:0007219 | Notch signaling pathway | 0.0464 |
| GO:0051782 | Negative regulation of cell division | 0.0478 |
| GO:0060449 | Bud elongation involved in lung branching | 0.0478 |
| GO:0045656 | Negative regulation of monocyte differentiation | 0.0478 |
| GO:0060687 | Regulation of branching involved in prostate gland morphogenesis | 0.0478 |
| GO:0033209 | Tumor necrosis factor–mediated signaling pathway | 0.0494 |
| Cgyps1–11Δ–infected THP-1 macrophages | ||
| Up-regulated DEGs | ||
| GO:0051607 | Defense response to virus | 0.0253 |
| GO:0009615 | Response to virus | 0.0381 |
| GO:0007420 | Brain development | 0.0395 |
| GO:0006139 | Nucleobase-containing compound metabolic process | 0.0430 |
| Down-regulated DEGs | ||
| GO:0060412 | Ventricular septum morphogenesis | 0.0051 |
| GO:0032729 | Positive regulation of interferon-γ production | 0.0125 |
| GO:0001570 | Vasculogenesis | 0.0182 |
| GO:0061156 | Pulmonary artery morphogenesis | 0.0183 |
| GO:0007179 | Transforming growth factor β receptor signaling pathway | 0.0454 |
| GO:0001916 | Positive regulation of T cell–mediated cytotoxicity | 0.0470 |
| GO:0051145 | Smooth muscle cell differentiation | 0.0470 |
| GO:0008584 | Male gonad development | 0.0472 |