Figure 9.

Importance of the activation loop. A, surface representation of DAD2 in complex with tolfenamic acid. Tolfenamic acid bound inside the cavity is drawn in cyan, and residues from the activation loop (Gln²¹³–Ala²²²) are shown in green. B, same as A with DAD2 drawn in ribbon mode. Ser²¹⁹ is drawn in stick mode (green) and indicated. The part of the lid that undergoes conformation change when interacting with MAX2 is colored in orange. C, structure of the D14-D3 complex (PDB entry 5HZG). D14 is colored with the same color scheme as DAD2 in B. The disordered activation loop is represented by a green dashed line. D3 is shown in brown.