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Quantification of association between IGF1R and selected adaptor proteins by BRET. Data are expressed as the BRET values for the IGF1-treated samples divided by the BRET values for the vehicle-treated samples. Linear lines-of-best-fit were included to highlight trends. Clear depression of association between IGF1R and IRS1, and between IGF1R and SHC1 can be seen in the case of SNX6 knockdown. Data points represent means of five independent experiments.
