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. 2018 Mar 7;293(17):6623–6634. doi: 10.1074/jbc.RA117.000100

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Figure 2. — Nuclear SREBP-1 protein stability is enhanced by PKM2. A, sections of human HCC tissues were stained with anti-SREBP-1 or anti-PKM2 antibody. Representative tissue images are shown (scale bar, 50 μm). B, semi-quantitative analyses of immunohistochemistry data of human HCC tissues for PKM2 or SREBP-1. Correlation between PKM2 and SREBP-1a was analyzed by Spearman rank correlation analysis. C, effects of PKM2 knockdown by siRNA on endogenous SREBP-1 protein levels in HepG2 cells. D, effects of PKM2 knockdown on the degradation of overexpressed FLAG–nBP1a in the presence of CHX. E, semi-quantitative analyses by densitometry of the effects of PKM2 knockdown on the degradation of overexpressed FLAG–nBP1a (n = 3). F, effects of the proteasome inhibitor MG132 on PKM2 regulation of overexpressed FLAG–nBP1a.