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. 2018 Mar 7;293(17):6623–6634. doi: 10.1074/jbc.RA117.000100

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Figure 5. — PKM2 regulates SREBP-1-dependent cancer cell growth. A, effects of SREBP-1 depletion and PKM2 overexpression on cell growth of HepG2, SW480, A549, or MCF7 cells. B, effects of the indicated compounds on PKM2-induced increase of HepG2 cell growth. C, generation of SREBP-1-knockout HepG2 cells. D, effects of overexpressed WT or the indicated mutant nBP1a on HepG2 cell growth. E, growth curve of xenograft tumors from SREBP-1 knockout HepG2 cells that were stably transfected with vector control, PKM2, WT, or T59A mutant nBP1a in nude mice. F, weight of tumors from stably transfected SREBP-1 knockout HepG2 cells when mice were sacrificed. G, effects of PKM2 knockdown on HepG2 cell growth. (*, p < 0.05; **, p < 0.01 versus control; n.s., not significant.)