Table 3.

Univariable and multivariable Cox regression analyses for the composite endpoint of all-cause mortality and readmission due to heart failure

	Composite endpoint		All-cause mortality		Readmission due to HF
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
PAPP-A
Univariable	1.25 (1.09–1.42)	0.001	1.30 (1.12–1.51)	0.001	1.08 (0.85–1.38)	0.525
Adjusted	1.13 (0.94–1.35)	0.185	1.10 (0.90–1.35)	0.340	0.94 (0.65–1.35)	0.729
Stanniocalcin-2
Univariable	2.90 (1.81–4.64)	< 0.001	2.52 (1.47–4.29)	0.001	5.37 (2.35–12.26)	< 0.001
Adjusted	2.06 (1.13–3.75)	0.018	2.23 (1.16–4.29)	0.017	3.42 (1.22–9.60)	0.020
IGFBP-4
Univariable	3.29 (2.47–4.39)	< 0.001	3.18 (2.30–4.39)	< 0.001	2.69 (1.83–3.97)	< 0.001
Adjusted	1.73 (1.14–2.64)	0.010	1.44 (0.85–2.44)	0.170	0.82 (0.42–1.60)	0.562
Hs-TnT
Univariable	1.48 (1.32–1.65)	< 0.001	1.44 (1.27–1.63)	< 0.001	1.64 (1.36–1.98)	< 0.001
Adjusted	1.07 (0.91–1.25)	0.424	1.04 (0.87–1.25)	0.665	1.00 (0.81–1.26)	0.959
NT-ProBNP
Univariable	1.69 (1.54–1.84)	< 0.001	1.66 (1.50–1.84)	< 0.001	1.68 (1.43–1.97)	< 0.001
Adjusted	1.21 (1.07–1.37)	0.002	1.18 (1.02–1.36)	0.028	1.24 (0.92–1.68)	0.157

All HRs (95% CIs) are reported per 1-SD increment of natural log-transformed plasma levels

hs-TnT high-sensitivity troponin T, PAPP-A pregnancy-associated plasma protein-A, IGFBP-4 insulin-like growth factor binding protein-4