Fig. (1).

Experimental human endometriosis in a nude mouse. Proliferative phase human endometrial tissue readily establishes ectopic lesions in a nude mouse. Prior to injection of endometrial fragments, mice are ovariectomized and provided a slow-release estradiol capsule to mimic the human proliferative phase. Lesions developing in mice are markedly similar to human disease both macroscopically (A) and microscopically following hematoxylin and eosin staining (B). Results are representative of numerous (N>25) experiments using different human samples.