Table 1.

Inclusion and exclusion criteria.

Inclusion Criteria

Exclusion Criteria

Studies involving adult patients (both genders) Isolated GHD GHD in concomitance with panhypopituitarism only if compensated by hormonal therapy since at least 3 months Randomized-controlled clinical trials Placebo-controlled studies Open-label studies Non interventional follow-up studies Data from Registries (real world practice)

Systematic reviews and meta-analysis Articles in language other than English Studies involving patient aged less than 18 GHD associated with other diseases that may require GH supplementation as a support therapy Uncompensated panhypopituitarism Obesity GHD in patients with previous acromegaly Adult survival of Leukemia in pediatric age Surveillance studies Cross-sectional studies GHD studies without data about replacement Unavailability of data of interest