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. 2018 Apr 23;9:183. doi: 10.3389/fendo.2018.00183

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Copyright © 2018 Hojo and Kawato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Biosynthetic pathway of steroids in rat hippocampus [modified from Ref. (11)]. Estrogens, androgens, and corticosteroids are represented with pink, blue, and orange boxes, respectively. (B,C) Relationship between the level of plasma T and those of hippocampal androgens [T and dihydrotestosteron (DHT)] (A), or that of hippocampal E2 (B). Vertical axis represents hippocampal steroids and horizontal axis represents plasma T, a precursor of DHT and E2. The regression lines and Pearson’s “r” are indicated [modified from Ref. (37)].