Table 2.
Gray matter differences between CD group and HC group by VBM analysis.
| Region (hemisphere) | Cluster size (voxels) | MNI coordinates |
Peak t-value | Regional volume (Mean ± SD) |
Feature weight (Mean ±SD) | |||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | CD (mm3) | HCs (mm3) | ||||
| CD > HCs | ||||||||
| Medial frontal gyrus/anterior cingulate(L) | 9392 | -2 | 51 | 7 | 5.1 | 11515.8 ± 1314.4 | 10317.4 ± 1330.0 | 0.5 ± 0.1 |
| Precuneus(L) | 1666 | -44 | -75 | 37 | 4.3 | 2093.0 ± 438.4 | 1761.7 ± 486.6 | 0.2 ± 0.1 |
| Superior parietal lobule(L) | 478 | -32 | -64 | 63 | 3.8 | 245.8 ± 57.0 | 205.3 ± 60.3 | 0.4 ± 1.8 |
| Superior frontal gyrus(R) | 318 | 21 | 62 | -26 | 3.8 | 221.1 ± 56.0 | 187.1 ± 46.6 | 0.6 ± 1.6 |
| Subthalamic nucleus(R) | 375 | 6 | -16 | -14 | 4.3 | 155.4 ± 32.5 | 135.3 ± 18.6 | 2.0 ± 1.8 |
| CD < HCs | ||||||||
| Cerebellum posterior lobe(R) | 210 | 15 | -39 | -51 | -3.9 | 166.3 ± 26.0 | 184.6 ± 25.7 | -2.6 ± 1.7 |
| Inferior parietal lobule/insula(R) | 1088 | 56 | -18 | 22 | -4.7 | 1618.2 ± 275.3 | 1870.7 ± 388.1 | -2.3 ± 0.4 |
| Lingual gyrus(R) | 71 | 5 | -94 | -18 | -3.6 | 32.0 ± 13.1 | 41.4 ± 15.6 | -1.7 ± 1.6 |
CD, conduct disorder; HCs, healthy controls; L, left hemisphere; R, right hemisphere; MNI, Montreal Neurological Institute; SD, standard deviation. The volume of each cluster was calculated by multiplying the voxel size of smoothed GM images by the sum of all the values of the voxels in this cluster. In SVM with linear kernel, the importance of a feature is represented by its weight, which is the coefficient in the training model. The absolute value of weight represents the importance of the feature and the direction represents the predicted label.