Table 3.
Phenotypic and toxin genetic characteristics of Staphylococcus aureus and MRSA isolates between neonates and mothers (nares and vagina) in Shenzhen, 2015, n (%)
| Characteristics |
S. aureus
|
MRSA
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Neonates (n=60) | Mothers, nasal (n=473) | Mothers, vaginal (n=133) | P-valuea | P-valueb | Neonates (n=15) | Mothers, nasal (n=104) | Mothers, vaginal (n=31) | P-valuea | P-valueb | |
| Phenotypic (resistant) | ||||||||||
| EM | 28 (46.7) | 224 (47.4) | 67 (50.4) | 0.920 | 0.633 | 13 (86.7) | 80 (76.9) | 24 (77.4) | 0.518 | 0.696 |
| PCN | 56 (93.3) | 433 (91.5) | 123 (92.5) | 0.635 | 1.000 | 13 (86.7) | 101 (97.1) | 29 (93.6) | 0.119 | 0.587 |
| GM | 5 (8.3) | 31 (6.6) | 11 (8.3) | 0.585 | 1.000 | 2 (13.3) | 6 (5.8) | 5 (16.1) | 0.265 | 1.000 |
| CM | 17 (28.3) | 163 (34.5) | 55 (41.4) | 0.344 | 0.083 | 10 (66.7) | 60 (57.7) | 20 (64.5) | 0.509 | 0.886 |
| RFP | 5 (8.3) | 37 (7.8) | 3 (2.3) | 0.802 | 0.110 | 3 (20.0) | 25 (24.0) | 2 (6.5) | 1.000 | 0.311 |
| LZD | 2 (3.3) | 16 (3.4) | 5 (3.8) | 1.000 | 1.000 | 1 (6.7) | 5 (4.8) | 3 (9.7) | 0.563 | 1.000 |
| MXF | 3 (5.0) | 40 (8.5) | 18 (13.5) | 0.457 | 0.078 | 3 (20.0) | 6 (5.8) | 9 (29.0) | 0.086 | 0.723 |
| TMP/SMX | 8 (13.3) | 40 (8.5) | 19 (14.3) | 0.214 | 0.860 | 4 (26.7) | 13 (12.5) | 6 (19.4) | 0.227 | 0.706 |
| TEC | 12 (20.0) | 227 (48.0) | 108 (81.2) | 0.000 | 0.000 | 4 (26.7) | 54 (51.9) | 23 (74.2) | 0.067 | 0.002 |
| TOB | 11 (18.3) | 109 (23.0) | 36 (27.1) | 0.410 | 0.191 | 2 (13.3) | 21 (20.2) | 12 (38.7) | 0.733 | 0.099 |
| MDR | 23 (38.3) | 244 (51.6) | 86 (64.7) | 0.053 | 0.001 | 12 (80.0) | 83 (79.8) | 26 (83.9) | 1.000 | 1.000 |
| Toxin genetic (positive) | ||||||||||
| Pvl | 3 (5.0) | 22 (4.7) | 3 (2.3) | 0.753 | 0.377 | 0 (0) | 13 (12.5) | 2 (6.5) | 0.368 | 1.000 |
| Tst | 2 (3.3) | 11 (2.3) | 3 (2.3) | 0.648 | 0.647 | 0 (0) | 3 (2.9) | 1 (3.2) | 1.000 | 1.000 |
| Eta | 7 (11.7) | 13 (2.8) | 4 (3.0) | 0.004 | 0.037 | 2 (13.3) | 2 (1.9) | 1 (3.2) | 0.077 | 0.244 |
| Etb | 0 (0) | 1 (0.2) | 0 (0) | 1.000 | NA | 0 (0) | 1 (1.0) | 0 (0) | 1.000 | NA |
Notes:
P-value was calculated as the proportion of S. aureus/MRSA isolates between neonates and mothers’ nares.
P-value was calculated as the proportion of S. aureus/ MRSA isolates between neonates and mothers’ vaginas. MDR, multidrug resistance, resistant to no less than three antibiotic classes.
Abbreviations: MRSA, methicillin-resistant S. aureus; n, number of isolates; EM, erythromycin; PCN, penicillin; GM, gentamicin; CM, clindamycin; RFP, rifampicin; LZD, linezolid; MXF, moxifloxacin; TEC, teicoplanin; TOB, tobramycin; TMP/SMX, trimethoprim-sulfamethoxazole; Pvl, Panton–Valentine leukocidin; Tst, toxic shock syndrome toxin; Eta, exfoliative toxin A; Etb, exfoliative toxin B; NA, not applicable.