Table 2.

HRs (95% CIs) of all-cause mortality across different combinations based on change in serum ferritin and ISAT in case-mix + MICS adjusted models. Reference group was no change in serum ferritin (−100 to <100 ng/mL/quarter) and rise in ISAT

Change in serum ferritin, ng/mL/quarter	Change in ISAT between PQ1 and PQ2
	drop in ISAT			rise in ISAT
	HR	95% CI	p value	HR	95% CI	p value
<−400	0.99	0.91–1.08	0.86	1.03	0.94–1.13	0.57
−400 to <−100	1.02	0.96–1.08	0.52	1.03	0.97–1.09	0.35
−100 to <100	1.06	1.00–1.12	0.03	Ref.
100 to <400	1.08	1.01–1.15	0.02	1.06	1.02–1.10	0.01
≥400	1.11	1.02–1.22	0.02	1.22	1.17–1.28	<0.01

HR, hazard ratio; ISAT, iron saturation; MICS, malnutrition-inflammation-cachexia syndrome; PQ, patient quarter; ref., reference.