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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Neurobiol Dis. 2018 Mar 2;114:1–16. doi: 10.1016/j.nbd.2018.02.003

Fig. 3.

Fig. 3

Aβ Fibrils affect mitochondrial trafficking to a greater extent than soluble Aβ peptides. (a) TEM of Aβ40 and Aβ39E22Δ fibrils 7 days after preparation. Concentration of all peptides is 100 μM. Scale bar, 200 nm. (b) Rates of mitochondrial trafficking in live embryonic (E17) cortical neurons treated with Aβ40 and Aβ39E22Δ peptides prepared using NH4OH or Aβ40 and Aβ39E22Δ fibrils (fib). Concentrations of peptides are in μM. *, p < 0.01 (t-test compared to untreated neurons). At least 15 neurons from 3 independent cultures were analyzed for each experiment. 35–70 individual organelles were taken into the analysis for each condition.