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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Neurobiol Dis. 2018 Mar 2;114:1–16. doi: 10.1016/j.nbd.2018.02.003

Fig. 4.

Fig. 4

Aβ Fibrils have a direct contact with neurites containing mitochondria in the hippocampal brain tissue of young and old APP/PS1 mice. (a, b) Low magnification EM micrograph showing an amyloid plaque (P) surrounded by dystrophic neurites (arrows) in the hippocampal CA1 region of a 6-months-old (a) and 22-months old (b) APP/PS1 mice. Dystrophic neurites are filled with vesicles that contain electron-dense material. Asterisks denote neuritis with mitochondria. (a) Scale bar, 1 μm. (b) Scale bar, 2 μm. (c, d) High magnification EM micrographs of amyloid fibrils (F) located in close proximity to neurites containing mitochondria (M) in the brain tissue of young (c) and old (d) APP/PS1 mice. Individual fibrils (F) could be clearly seen. Scale bars: (c) 50 nm; (d) 200 nm.