The experimental design is illustrated at the top of the figure. Subjects that received DIOA or its vehicle (Veh) are shown in black and white, respectively. Groups given bicuculline (Bic) or its vehicle (Veh) are depicted with squares and circles, respectively. The y-axis depicts the change from baseline after DIOA and bicuculline treatment (Post Drug), and 0, 1, 2, 3 hr after capsaicin treatment (Post Cap). The error bars depict ± SEM.