The experimental design is illustrated at the top of the figure. Subjects that received bicuculline (Bic) or its vehicle (Veh) are depicted as squares and circles, respectively. Groups given LPS or nothing (Veh) are shown in black and white, respectively. The y-axis depicts the change from baseline scores averaged across test leg after bicuculline (Post Drug), and 0, 1, 2, 3 hr after LPS (Post LPS), treatment. The error bars depict ± SEM.