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Effect of an agonist of sirtuins on NAT1 and NAT2 activity. Peripheral blood mononuclear cells (PBMC) were cultured with different concentrations of a sirtuin agonist (resveratrol, RSV: 0, 10, 50 and 100 µmol/L) for 3 h and, subsequently, with p-aminobenzoic acid (PABA) or isoniazid (INH) were added. NAT1 (A) and NAT2 (B) activity expressed in nmol of metabolite/min/mg of protein was determined by HPLC. PABA or INH concentrations = 10, 30 and 100 µmol/L. M, mol/L.
