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. 2018 Apr 24;19:54. doi: 10.1186/s13059-018-1430-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Overlaps between HOCIs and super-enhancers. a Identification of super-enhancers in U266 cells based on E2F1 or DP1 signals. b Venn diagram showing the overlap between the two types of super-enhancers defined by E2F1 or DP1 signals (U266). c The length distribution of the two types of super-enhancers defined by E2F1 or DP1 signals (U266). SE super-enhancer. d Proportions of super-enhancers overlapping HOCIs. e Venn diagram showing the overlap between super-enhancers and HOCIs. The p values were generated using Fisher test. f The browser view of a genomic region in chromosome 14, showing HOCI-mediated chromatin interactions within and between super-enhancers (GM12878). OCEAN-C interaction: both ends of OCEAN-C read pairs mapped to HOCIs. Pink, interactions between super-enhancer-related enhancer HOCIs; gray, all interactions