Fig. 2.

Participant timeline (SPIRIT figure). (x) = Patients without parasite clearance. * Intensive paracetamol level sampling will be performed on a subset of patients at 0.5, 1.5, 2.5, 4.0, 72.5, 73.5, 74.5 and 76.0 h, in addition to 6-hourly as above. AE adverse event, BUSE blood urea and serum electrolytes, LFTs liver function tests (including bilirubin), CFHb cell-free haemoglobin, FBC full blood count, HCT haematocrit, F₂-IsoP F₂-isoprostanes, F₂-IsoF F₂-isofurans, WPB Weibel–Palade bodies, Ang-2 angiopoietin-2, vWF von-Willebrand factor, OPG osteoprotegerin, ACR albumin:creatinine ratio, NGAL neutrophil gelatinase-associated lipocalin