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The [PRION+] state is a node that integrates diverse cell-intrinsic inputs (on short and long time scales) and cell-extrinsic stimuli, and actuates diverse phenotypic outputs. The naïve state is shown as a blue gene product; the prion-like [PRION+] state is shown as an orange gene product. Shown are selected examples of inputs and outputs of the [PRION+] state; this diagram is not exhaustive.
