Table 1.

Recent descriptions of prion-like behavior in biochemical processes involved in normal cellular function. See also [10,37] for systematic approaches to identify prion-like behavior proteome-wide in S. cerevisiae.

Biochemical process	Gene product exhibiting prion-like behavior	Species/cell line	Reference
Long-term memory formation	CPEB3	M. musculus	[26]
	Orb2	D. melanogaster	[25]
	CPEB4	X. laevis	[27]
Antiviral signaling	MAVS	HEK293T (H. sapiens)	[28]
Stress granule formation	TIA-1/Sup35	COS-7 (C. aethiops); S. cerevisiae	[30,31]
Transcription termination	Rho	E. coli	[32]
Heterokaryon incompatibility	HET-s (HET-s/HET-S)	P. anserina	[33]
Translation termination	SUP35 ([PSI+])	S. cerevisiae	[34]
Pyrimidine biosynthesis	URE2 ([URE3+])	S. cerevisiae	[35]
Chromatin remodeling	Swi1 ([SWI+])	S. cerevisiae	[36]
Mating; carbon metabolism; stress response	Mot3 ([MOT3+])	S. cerevisiae	[37]
Sterol biosynthesis	Mod5 ([MOD+])	S. cerevisiae	[38]
Carbon metabolism	Various ([GAR+])	S. cerevisiae	[39]
Prion formation	New1 ([PIN+])	S. cerevisiae	[40]
Prion formation	Rnq1 ([PIN+])	S. cerevisiae	[41]