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Electrostatic potential surface map for (A) the transition state of PfHGXPRT and (B) the PfHGXPRT substrates, α-D-ribose 1-phosphate (to serve as a truncated PRPP) and hypoxanthine. Hypoxanthine is shown as the neutral N-9-protonated structure, the favored ground state. During the reaction coordinate, N-7-protonated hypoxanthine forms and is the reactive species at the transition state.
