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. Author manuscript; available in PMC: 2019 Apr 27.
Published in final edited form as: Circ Res. 2018 Apr 27;122(9):1276–1289. doi: 10.1161/CIRCRESAHA.117.310999

Figure 4.

Figure 4

A new strategy to stratify health prevention and identify early disease signs. Recovery time after exposure to a specific risk factor (stress test) can be a new biomarker to stratify patients. A, C) The individuals exhibit a very similar profile before stress test – although their resilience (width and steepness of the potential well) is different. B, D) After the stress test, omics profiling can identify the most variable proteins/metabolites for each individual (red boxes) enabling personalized recommendations. While the recovery time (t1 vs. t2) can identify the high-risk individuals (longer time, higher risk), who can be further profiled for early disease biomarkers (black boxes). U: landscape potential (Table 2).