MitoROS are produced as a normal byproduct of mitochondrial respiration and metabolic enzymatic activity. Under settings of increased ROS generation as a result of dysregulated enzymatic activity and cellular stress, mitoROS can influence metabolic pathways including the Krebs cycle, fatty acid synthesis, ATP generation, glycolysis and mitophagy. Cyto=cytoplasm, IMS=intermembrane space, LPP=lipid peroxidation product. Please refer to the abbreviation table for full names of listed proteins.