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. Author manuscript; available in PMC: 2019 Mar 16.
Published in final edited form as: Circ Res. 2018 Mar 16;122(6):877–902. doi: 10.1161/CIRCRESAHA.117.311401

Figure 2. Mitochondrial ROS production.

Figure 2

MitoROS are produced as a normal byproduct of mitochondrial respiration and metabolic enzymatic activity. Under settings of increased ROS generation as a result of dysregulated enzymatic activity and cellular stress, mitoROS can influence metabolic pathways including the Krebs cycle, fatty acid synthesis, ATP generation, glycolysis and mitophagy. Cyto=cytoplasm, IMS=intermembrane space, LPP=lipid peroxidation product. Please refer to the abbreviation table for full names of listed proteins.