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. Author manuscript; available in PMC: 2019 Mar 16.
Published in final edited form as: Circ Res. 2018 Mar 16;122(6):877–902. doi: 10.1161/CIRCRESAHA.117.311401

Figure 5. Inflammation and ROS.

Figure 5

Various inflammation-inducing stimuli including TNFα, LPS, thrombin and oscillatory shear stress influence ROS production through sources including NOX and the mitochondria. Elevated ROS production as a result of inflammatory signaling can mediate canonical NF-κB activation and downstream inflammatory gene induction, proteasome activity, antioxidant gene transcription, inflammasome activation and cytokine secretion. Full names for abbreviations are listed in the accompanying table.