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. 2018 Mar 22;3(6):e96272. doi: 10.1172/jci.insight.96272

Figure 2. Deletion of EC Panx1 significantly reduces stroke infarct volume.

Figure 2

Brains were isolated from mice following a 90-minute MCA occlusion and 24-hour reperfusion and stained with TTC to quantify infarct volume. Representative brains, in 2-mm sections, are shown for SMC Panx fl/fl (32.3% infarct, A), SMC Panx Δ/Δ mice (37.5% infarct, B), EC Panx1 fl/fl (38.9% infarct, D), EC Panx1 Δ/Δ mice (8.7% infarct, E), and Cre– Panx1 fl/fl (33.6% infarct, F). Quantification of infarct volume is shown for each genotype (C and G). SMC Panx1 fl/fl, n = 9; SMC Panx1 Δ/Δ, n = 11; EC Panx1 fl/fl, n = 9; EC Panx1 Δ/Δ, n = 9; Cre– Panx1fl/fl, n = 6 mice. *P < 0.05; 1-way ANOVA/Tukey’s multiple comparisons post hoc test vs. EC Panx1 fl/fl (P = 0.09 for EC Panx1 Δ/Δ vs. Cre– Panx1fl/fl).