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. 2018 Mar 22;3(6):e98459. doi: 10.1172/jci.insight.98459

Figure 3. HETE-PL restoration of hemostasis in mice lacking FVIII and enhancement of thrombin generation in FVIII deficiency, with/without tissue factor pathway inhibitor (TFPI) inhibition.

Figure 3

(A and B) Summary data for thrombin generation in plasma as shown in Figure 3, E–L (n = 3, mean ± SEM). **P < 0.01, compared with control, as determined by 1-way ANOVA and post hoc Tukey tests. (C and D) 12-HETE-PE restores hemostasis in mice lacking FVIII. Male mice (11 weeks) were administered 78 ng HETE-PE in liposomes as described in Methods before a 3-mm tail cut. Bleeding time and Hb loss were determined as in Methods (n = 4–9 mice per group). Data is shown as Tukey box plots, with 1-way ANOVA with Tukey post hoc multicomparison test. *P < 0.05, ***P < 0.005, data shown as squares in box plot are outliers (values 1.5–3 times lower or higher than the interquartile range).