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. 2018 Mar 22;3(6):e97918. doi: 10.1172/jci.insight.97918

Figure 7. ANGPTL4 deficiency in adipose tissue (AT) attenuates atherosclerosis.

Figure 7

(A–D) Body weight (A), triacylglycerols (TG) (B), total cholesterol (TC) (C), and HDL cholesterol (HDL-C) (D) from WT mice and in mice with AT-specific knockout of ANGPTL4 (Ad-KO) mice fed a Western diet (WD) for 16 weeks (n = 8). (E) Lipoprotein profile of pooled plasma isolated from WT and Ad-KO mice after 16 weeks on a Western diet (WD) (n = 5). (F and G) Representative histological analysis of cross sections of the aortic sinus isolated from WT and Ad-KO mice fed a WD for 16 weeks stained with H&E (F) (n = 10) and Oil Red O (ORO) (G) (n = 5). Quantification of the plaque size and percentage ORO area are shown in right panels. Scale bars: 200 μm. (H) Representative pictures from en face analysis of aortas isolated from WT and Ad-KO mice fed a WD for 16 weeks. Percentage ORO area is quantified on the right (n = 5). All data are the mean ± SEM. *P ≤ 0.05 comparing Ad-KO with WT mice by unpaired t test.