Figure 13. Allele-specific differences in HCM revealed by analysis of transcriptome and mitochondrial function in 2 mouse models — schematic summary.

(A) Summary of multiscale studies performed in R403Q-αMyHC and R92W-TnT mutant mice along with littermate controls at the early stage of HCM. We found differences in cardiac function, mRNA/miRNA expression, mitochondrial number, redox, calcium handling, signaling, and predicted therapies in the 2 mutant mice. (B) Based on our results and the redox-optimized ROS balance hypothesis (42), MyHC mutants appear to reside at an optimal reduced phase, whereas TnT mutants lie in a lower-energy oxidative phase. Figure adapted from ref. 42.j