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. 2018 Mar 22;3(6):e93626. doi: 10.1172/jci.insight.93626

Figure 3. Acox1Lampe1 mutation alters hepatic mitochondrial activity, hepatic inflammation, and hepatocellular damage.

Figure 3

(A) Representative liver histology (H&E staining; 20×) of chow diet–fed Acox1Lampe1 mice and WT littermate controls. E15; 2 weeks of age; and 12 weeks of age were analyzed. Representative hepatic H&E staining. (B–H) Characterization of liver phenotype and function in 12-week-old, chow diet–fed, Acox1Lampe1 mice and WT littermate controls. (B) Liver/body mass ratio. (C) Hepatic triglyceride (TG) levels. (D) Hepatic mitochondrial OCR. (E) Hepatic 4-hydroxynonenal (4-HNE) levels. (F) Serum alanine transaminase (ALT) levels. (G) Total hepatic immune (CD45+) cell infiltration determined by flow cytometry. (H) Hepatic chemokine mRNA expression of Cxcl10 and Ccl22. Data represent means ± SEM. (B–H) Unpaired Student’s t test; *P < 0.05, **P < 0.01, ***P < 0.001. White bars denote WT mice; black bars denote Acox1Lampe1 mice. (B–D) Representative of 3 individual experiments, n = 3/condition. (E, G, H) A single experiment, n = 3/condition. (F) Data combined from 2 independent experiments, n = 5–12/condition.