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. 2018 Mar 22;3(6):e99096. doi: 10.1172/jci.insight.99096

Figure 1. Untargeted metabolomics studies discover candidate compound with m/z of 189.1598 is associated with CVD and is trimethyllysine.

Figure 1

(A) Forest plot indicating plasma metabolite of unknown structure with m/z of 189.1 is associated with risk for cardiovascular disease (CVD) according to relative peak area intensity ranked by tertiles among subjects (N = 99) in discovery cohort 1. (B) Forest plot indicating plasma metabolite of unknown structure with high-resolution m/z of 189.1598 is associated with the risk for incident CVD and mortality risks according to relative peak intensity from untargeted mass spectrometry analyses of subjects (N = 1,162; discovery cohort 2). MACE, major adverse cardiac events, including myocardial infarction, stroke, or death. The analyses were performed using R 3.4.1. (C) Collision-induced dissociation (CID) spectrum in positive-ion mode of the metabolite m/z of 189.1598 in plasma. (D) CID spectra in positive mode of synthetic trimethyllysine (TML) standard. (E) Demonstration of cochromatography of multiple unique parent→daughter ion transitions for plasma analyte m/z 189.1598 and synthetic d9-TML.