Table 7.

Pharmacokinetic parameters of cefuroxime solution and CLN in plasma

Parameter	Cefuroxime standard	CLN
AUC0–x (µg h/mL)	129.15±4.53	247.70±5.76*
Cmax (µg/mL)	63.34±3.0	82.41±3.45*
Tmax (min)	60.00	60.00
T1/2 (h)	1.46±1.08	1.61±0.91*
Kel (1/h)	0.48±0.04	0.43±0.01**
Vd (L)	0.57±0.07	0.37±0.09*
CL (L/h)	0.27±1.32	0.16±2.11*

Notes: Each value represents the mean ± standard deviation (n=4).

^*Significant values (P<0.05) in comparison with cefuroxime solution.

^**Significant values (P>0.05).

Abbreviations: CL, clearance; CLN, cefuroxime-loaded nanoemulsion.