Fig 8. Knockdown of NF2 inhibits β-AR-stimulated apoptosis, while adenoviral-mediated expression of WT-NF2 induces apoptosis.

(A) ARVMs were transfected with NF2 siRNA or negative control siRNA (neg siRNA) for 24 h followed by treatment with ISO for 24 h. Apoptosis was measured using TUNEL assay. *p<0.05 vs CTL; ^$p<0.05 vs ISO or neg siRNA+ISO; n = 3–4. (B) ARVMs were infected with adenoviruses expressing WT-NF2 or GFP for 48 h. Apoptosis was measured using TUNEL assay. *p<0.05 vs GFP; n = 3–4.