Table 2. Adjusted hazard ratios of discontinuation.

	Hazard Ratio*	Hazard Ratio 95% Confidence Limits		P-value	Hazard Ratio*	Hazard Ratio 95% Confidence Limits		P-value
Warfarin	1.74	1.67	1.82	<0.001	1.00 Reference
Dabigatran	1.46	1.38	1.54	<0.001	0.84	0.80	0.87	<0.001
Rivaroxaban	1.23	1.17	1.28	<0.001	0.70	0.68	0.73	<0.001
Apixaban	1.00 Reference				0.57	0.55	0.60	<0.001
Covariates Included in Both Models Have the Same Estimates as Shown Below
			Hazard Ratio*		Hazard Ratio 95% Confidence Limits		P-value
Age (75+ as a reference category)
18–64			1.34		1.30	1.38	<0.001
65–74			0.99		0.96	1.03	0.554
Male			1.02		0.99	1.05	0.226
Embolic or Primary Ischemic Stroke			0.96		0.88	1.05	0.394
Dyspepsia or Stomach Discomfort			1.10		1.06	1.14	<0.001
Congestive Heart Failure			0.96		0.93	0.99	0.007
Coronary Artery Disease			1.01		0.98	1.04	0.557
Diabetes			0.89		0.87	0.92	<0.001
Hypertension			0.89		0.86	0.91	<0.001
Renal Disease			1.04		0.99	1.08	0.116
Myocardial Infarction			1.05		0.99	1.11	0.093
History of Stroke or Transient Ischemic Attack			0.85		0.79	0.92	<0.001
History of Bleeding			1.12		1.08	1.16	<0.001

*Adjusted hazard ratios were estimated from a Cox proportional hazards model with factors for age, sex, embolic or primary ischemic stroke, dyspepsia or stomach discomfort, congestive heart failure, coronary artery disease, diabetes, hypertension, renal disease, myocardial infarction, history of stroke or transient ischemic attack, and history of bleeding.