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. 2018 Apr 18;12(4):e0006420. doi: 10.1371/journal.pntd.0006420

Fig 7. Comparison of responses to TRPM8 ligands in wild type and TRPM8 KO mice.

Fig 7

(A-C) Responses to the TRPM8 agonists (A) menthol (300μM), (B) icilin (50μM) and (C) WS-12 (50μM) in wild type (WT, black) and TRPM8 knockout mice (TRPM8 KO, purple) when applied during the sustained phase of a KPSS-evoked contraction (shown by black circle). (D) Similar assay for (S)-PZQ (50μM) evoked relaxation during KPSS-evoked contraction in wild type (WT, black) and TRPM8 knockout mice (TRPM8 KO, purple). (E) Cumulative dataset measuring (S)-PZQ (50μM) evoked relaxation from experiments such as shown in (D). Data represent mean±s.e.m. from averaged measurements from mesenteric vessel strips from n≥3 mice.