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. 2016 Aug 22;9(3):203–215. doi: 10.1080/21541248.2016.1218407

Figure 3.

Figure 3.

The Rho GTPase family. (A) An amino acid identity matrix was generated by comparing the primary sequence of 20 human Rho proteins. Grouping into Rac (red), Rho (purple), RhoH (brown) and RhoBTB (green) groups was by hierarchical clustering using the Multalin multiple sequence alignment program.16 (B) A rooted phylogenetic tree of the 20 human Rho GTPases was generated by hierarchical clusing using the Multalin multiple sequence alignment program.16 Distances between proteins are proportional to their PAM (point accepted mutation) score of molecular evolution.