Table 2.
Main toxicities.
| Toxicities |
|||
|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3–4 | |
| Patient 1 | ↗Bilirubin | Thrombopenia, Anemia, ↗ASAT, ↗Alkaline phosphatase | ↗GGT |
| Patient 2 | Thrombopenia | Anemia | — |
| Patient 3 | ↗ASAT | Anemia, ↗Alkaline phosphatase | Thrombopenia |
| Patient 4 | Anemia, ↗ALAT | ↗Bilirubin, ↗Alkaline phosphatase | — |
| Patient 5 | Anemia, ↗ALAT, ↗Bilirubin | — | Thrombopenia |
| Patient 6 | — | Thrombopenia, Anemia | — |
| Patient 7 | ↗ASAT | Anemia | Thrombopenia |
| Patient 8 | ↗ASAT | ↗Alkaline phosphatase | Thrombopenia, Anemia |
| Patient 9 | — | Anemia, ↗Alkaline phosphatase | Thrombopenia, ↗GGT |
The adverse effects were graded according to CTCAE version 4.0.
Abbreviations: ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; GGT, gamma glutamyl-transpeptidase.