Figure 4.

Pulmonary PGIS overexpression has no effect on LLC orthotopic lung tumor progression and metastasis. LLC tumors were implanted in pulmonary PGIS overexpressing transgenic mice (PGIS OE, n = 5) or littermate controls (WT, n = 5). After 3 weeks, lungs, livers, and brains were harvested and imaged ex vivo with an IVIS 50 imaging system. (A) Primary tumor volumes were measured by digital calipers. Each point represents a single tumor. The incidence (B), number (C) and signal intensity (D) of liver and brain metastases were quantified by ex vivo bioluminescent imaging, ns = not significant.