Figure 6.

Heterogeneity of CD161-expressing CD4⁺ and CD8⁺ T cells within NSCLC tumors. (A-B) Correlation factors between KLRB1 gene expression and expression of genes from the “PanCancer Immune Profiling Panel” (NanoString Technologies) in highly purified intra-tumoral CD4⁺ T cells (A) or CD8⁺ T cells (B). Genes significantly correlated with KLRB1 (FDR < 0.05, 0.05 < FDR < 0.10, and up to 0.10 < FDR < 0.15) are shown. Vertical dashed lines represent limits for correlation factors <-0.5 and >+0.5. (C-D) Potential associations between genes positively (C) and negatively (D) correlated with KLRB1 in CD4⁺ T cells (FDR < 0.15) with corresponding pathways determined using ClueGo software.