Figure 7.

Higher frequencies of CD161-expressing central-memory CD4⁺ T cells in NSCLC tumors as compared to distant lung and peripheral blood. (A) Rings illustrating the mean percentages of naive, effector memory (EM), central memory (CM) and effectors (EMRA) subsets within CD161⁻ CD4⁺ or CD161⁺ CD4⁺ T cells (left panels), or within CD161⁻ CD8⁺ or CD161⁺ CD8⁺ T cells (right panels), in each compartment, n = 12. (B) Histograms representing the percentages of CD161 expression within each CD4⁺ (left panel) and CD8⁺ (right panel) T cell subsets in each compartment, n = 12. Means are indicated by red horizontal lines. *p <0.05 (One-way anova/Kruskal-Wallis/Dunn's test). (C) Mean percentages of CD161 expression within each CD4⁺ (left panel) and CD8⁺ (right panel) T cell subsets in matched compartments, n = 11. *p<0.05, **p<0.005 (One-way anova/Friedman/Dunn's test).